期刊
MOLECULES
卷 26, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/molecules26082374
关键词
multidrug resistance (MDR); efflux pump inhibitor; AcrAB-TolC pump; quinazoline; molecular docking; UV-Vis spectroscopy; FTIR spectroscopy
资金
- Romanian National Authority for Scientific Research and Innovation, CNCS/CCCDI-UEFISCDI [PN-III-P1-1.1-PCCDI-2017-0728, PN-III-P2-2.1-PED2019-4771, PN-III-P2-2.1-PED-2019-1264, PN-III-P2-2.1-PED-2019-5283]
- Nucleu Programme [16N/08.02.2019]
The study investigates the potential of BG1189 and BG1190 as efflux pump inhibitors through in silico and molecular docking approaches. The findings suggest that these compounds could be attractive candidates for antimicrobial drugs. UV-Vis absorption spectroscopy and FTIR spectroscopy were utilized to study the stability and effects of laser radiation on the molecules.
Multidrug resistance of bacteria is a worrying concern in the therapeutic field and an alternative method to combat it is designing new efflux pump inhibitors (EPIs). This article presents a molecular study of two quinazoline derivatives, labelled BG1189 and BG1190, proposed as EPIs. In silico approach investigates the pharmacodynamic and pharmacokinetic profile of BG1189 and BG1190 quinazolines. Molecular docking and predicted ADMET features suggest that BG1189 and BG1190 may represent attractive candidates as antimicrobial drugs. UV-Vis absorption spectroscopy was employed to study the time stability of quinazoline solutions in water or in dimethyl sulfoxide (DMSO), in constant environmental conditions, and to determine the influence of usual storage temperature, normal room lighting and laser radiation (photostability) on samples stability. The effects of irradiation on BG1189 and BG1190 molecules were also assessed through Fourier-transform infrared (FTIR) spectroscopy. FTIR spectra showed that laser radiation breaks some chemical bonds affecting the substituents and the quinazoline radical of the compounds.
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