4.6 Review

Engineering Polymeric Nanosystems against Oral Diseases

期刊

MOLECULES
卷 26, 期 8, 页码 -

出版社

MDPI
DOI: 10.3390/molecules26082229

关键词

nanotechnology; polymeric nanoparticles; oral diseases; oral medicine; caries; restorative dentistry; endodontology; periodontology; oral cancer; pre-clinical models; clinical studies

资金

  1. ERC-2019-STG [850936]
  2. Fondazione Cariplo [2019-4278]
  3. Programma Operativo Nazionale (PON) Ricerca e Innovazione 2014-2020 Asse I Capitale Umano, Azione I.2, Avviso A.I.M: Attraction and International Mobility [CUP F88D18000070001]
  4. European Research Council (ERC) [850936] Funding Source: European Research Council (ERC)

向作者/读者索取更多资源

Nanotechnology and nanoparticles play a crucial role in modern research, especially in healthcare therapeutic applications. Polymeric nanoparticles show great promise for treating oral diseases, but careful optimization in production and thorough biological considerations and clinical evaluations are necessary for successful clinical application.
Nanotechnology and nanoparticles (NPs) are at the forefront of modern research, particularly in the case of healthcare therapeutic applications. Polymeric NPs, specifically, hold high promise for these purposes, including towards oral diseases. Careful optimisation of the production of polymeric NPs, however, is required to generate a product which can be easily translated from a laboratory environment to the actual clinical usage. Indeed, considerations such as biocompatibility, biodistribution, and biodegradability are paramount. Moreover, a pre-clinical assessment in adequate in vitro, ex vivo or in vivo model is also required. Last but not least, considerations for the scale-up are also important, together with an appropriate clinical testing pathway. This review aims to eviscerate the above topics, sourcing at examples from the recent literature to put in context the current most burdening oral diseases and the most promising polymeric NPs which would be suitable against them.

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