A Review on Coordination Properties of Al(III) and Fe(III) toward Natural Antioxidant Molecules: Experimental and Theoretical Insights

This review focuses on the ability of some natural antioxidant molecules (i.e., hydroxycinnamic acids, coumarin-3-carboxylic acid, quercetin, luteolin and curcumin) to form Al(III)- and Fe(III)-complexes with the aim of evaluating the coordination properties from a combined experimental and theoretical point of view. Despite the contributions of previous studies on the chemical properties and biological activity of these metal complexes involving such natural antioxidants, further detailed relationships between the structure and properties are still required. In this context, the investigation on the coordination properties of Al(III) and Fe(III) toward these natural antioxidant molecules might deserve high interest to design water soluble molecule-based metal carriers that can improve the metal's intake and/or its removal in living organisms.

Automated summary

This review focuses on the ability of some natural antioxidant molecules to form complexes with Al(III) and Fe(III) with the aim of evaluating their coordination properties. Further research is needed to explore the relationships between structure and properties. Investigating the coordination properties of these natural antioxidant molecules with Al(III) and Fe(III) could lead to the design of water soluble molecule-based metal carriers for improved metal intake and/or removal in living organisms.