期刊
MOLECULES
卷 26, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/molecules26102846
关键词
polylactide; stereocomplex; biodegradable polymers; drug delivery system; biomedical applications
资金
- Ministry of Trade, Industry and Energy, Republic of Korea [20008686]
- KIST Institutional Program
- KU-KIST Graduate School of Converging Science and Technology Program
- Korea Evaluation Institute of Industrial Technology (KEIT) [20008686] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Polylactide (PLA) is a common biodegradable polymer with sustainable, eco-friendly, and fully biodegradable properties. Stereocomplex PLA (sc-PLA) has improved mechanical and physical strength compared to homopolymers, making it suitable for applications in drug delivery systems.
Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared to the homopolymer, overcoming these limitations. Recently, numerous studies have reported the use of sc-PLA as a drug carrier through encapsulation of various drugs, proteins, and secondary molecules by various processes including micelle formation, self-assembly, emulsion, and inkjet printing. However, concerns such as low loading capacity, weak stability of hydrophilic contents, and non-sustainable release behavior remain. This review focuses on various strategies to overcome the current challenges of sc-PLA in drug delivery systems and biomedical applications in three critical fields, namely anti-cancer therapy, tissue engineering, and anti-microbial activity. Furthermore, the excellent potential of sc-PLA as a next-generation polymeric material is discussed.
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