4.6 Article

Multiple Roles of Black Raspberry Anthocyanins Protecting against Alcoholic Liver Disease

期刊

MOLECULES
卷 26, 期 8, 页码 -

出版社

MDPI
DOI: 10.3390/molecules26082313

关键词

black raspberry; anthocyanins; alcoholic liver injury; antioxidant; apoptosis

资金

  1. Doctoral Fund of Guizhou Medical University [[2018] 013]
  2. Fund of Science and Technology Project of Guizhou provincial health commission [2019-1-181]
  3. Fund of Traditional Chinese Medicine and Ethnic Medicine Science and Technology in Guizhou Province [QZYY-2019-059]
  4. Guizhou Medical University Breeding programs of National Natural Science Foundation of China [19NSP074]

向作者/读者索取更多资源

The study demonstrated that black raspberry anthocyanins (BRAs) have a protective effect against acute and subacute alcoholic liver disease (ALD) by exerting preventive effects through antioxidant and apoptosis pathways.
This study aimed to investigate the protective effect of black raspberry anthocyanins (BRAs) against acute and subacute alcoholic liver disease (ALD). Network analysis and docking study were carried out to understand the potential mechanism. Thereafter, the serum biochemical parameters and liver indexes were measured, the histopathological changes of the liver were analyzed in vivo. The results showed that all tested parameters were ameliorated after the administration of BRAs with alcohol. Meanwhile, there was increased protein expression of NF-kappa B and TGF-beta in extracted livers, which was associated with hepatitis and hepatic fibrosis. Furthermore, BRAs and cyanidin-3-O-rutinoside exhibited cytotoxic effects on t-HSC/Cl-6, HepG2, and Hep3B and induced the apoptosis of HepG2 cells; downregulated the protein expression level of Bcl-2; upregulated the level of Bax; and promoted the release of cytochrome C, cleaved caspase-9, cleaved caspase-3, and cleaved PARP in HepG2 cells. In addition, the antioxidant activity of BRAs was tested, and the chemical components were analyzed by FT-ICR MS. The results proved that BRAs exert preventive effect on ALD through the antioxidant and apoptosis pathways.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据