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Paolo Lazzari et al.
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Shan-Shan Li et al.
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K. Banerjee et al.
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Giansalvo Pinna et al.
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Giovanni Pinna et al.
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Sangdon Han et al.
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Peng Yang et al.
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Andrea Mastinu et al.
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L. Luongo et al.
NEUROBIOLOGY OF DISEASE (2010)
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Yanan Zhang et al.
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Dan Jones
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A Hosseini et al.
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F Pi-Sunyer et al.
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JP Gong et al.
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The endocannabinoid system: Drug targets, lead compounds, and potential therapeutic applications
DM Lambert et al.
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CB2 cannabinoid receptors in trabecular meshwork cells mediate JWH015-induced enhancement of aqueous humor outflow facility
LC Zhong et al.
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I Tomida et al.
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Tricyclic pyrazoles.: part 1:: Synthesis and biological evaluation of novel 1,4-dihydroindeno[1,2-c]pyrazol-based ligands for CB1 and CB2 cannabinoid receptors
JM Mussinu et al.
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Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract
MA Casu et al.
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Reduction of intraocular pressure and glaucoma progression - Results from the early manifest glaucoma trial
A Heijl et al.
ARCHIVES OF OPHTHALMOLOGY (2002)
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AR Stoit et al.
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The role of cannabinoids in neurodegenerative diseases
M Glass
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A Porcella et al.
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QJ Lu et al.
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