Biodegradable and Biocompatible Silatrane Polymers

In this study, new biodegradable and biocompatible amphiphilic polymers were obtained by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The structures of the synthesized polymers were confirmed by NMR and GPC. Organosilicon moieties of the polymers were formed by silatranes and trimethylsilyl blocks and displayed hydrophilic and hydrophobic properties, respectively. The effect of the ratio of hydrophilic to hydrophobic organosilicon structures on the surface activity and biological activity of macromolecules was studied, together with the effect on these activities of the macromolecules' molecular weight and chemical structure. In particular, the critical micelle concentrations were determined, the effect of the structure of the polymers on their wetting with aqueous solutions on glass and parafilm was described, and the aggregation stability of emulsions was studied. Finally, the effect of the polymer structures on their antifungal activity and seed germination stimulation was examined.

Automated summary

This study focused on synthesizing biodegradable and biocompatible amphiphilic polymers by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The research investigated the impact of the ratio of hydrophilic to hydrophobic organosilicon structures on the biological activity of macromolecules, as well as the influence of polymer structure on critical micelle concentrations and aggregation stability of emulsions. Additionally, the study explored how polymer structures affected antifungal activity and seed germination stimulation.