期刊
MOLECULES
卷 26, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/molecules26082185
关键词
chitosan; oxidized carboxymethyl cellulose; hydrogel film; curcumin immobilization; delivery system
资金
- ERASMUS+ International Dimension Programme for the studentship at the University of Iasi, Romania
Cross-linked chitosan (CS) films with aldehyde groups were prepared using oxidation of carboxymethyl cellulose (CMC) with NaIO4. The presence of aldehyde groups in the oxidized carboxymethyl cellulose (CMCOx) was confirmed by FTIR and NMR spectroscopy. The study showed that the cross-linking conditions and molar ratio of -CHO/-NH2 affected the curcumin encapsulation efficiency, release efficiency, and skin membrane permeability. Increasing cross-linking degree resulted in decreased encapsulation efficiency and release efficiency of curcumin, but also influenced the absorption of curcumin in the skin membrane.
Cross-linked chitosan (CS) films with aldehyde groups obtained by oxidation of carboxymethyl cellulose (CMC) with NaIO4 were prepared using different molar ratios between the CHO groups from oxidized carboxymethyl cellulose (CMCOx) and NH2 groups from CS (from 0.25:1 to 2:1). Fourier-transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopy demonstrated the aldehyde groups' presence in the CMCOx. The maximum oxidation degree was 22.9%. In the hydrogel, the amino groups' conversion index value increased when the -CHO/-NH2 molar ratio, cross-linking temperature, and time increased, while the swelling degree values decreased. The hydrogel films were characterized by scanning electron microscopy (SEM) and FTIR analysis. The curcumin encapsulation efficiency decreases from 56.74% to 16.88% when the cross-linking degree increases. The immobilized curcumin release efficiency (R-Ef%) and skin membrane permeability were evaluated in vitro in two different pH solutions using a Franz diffusion cell, and it was found to decrease when the molar ratio -CH=O/NH2 increases. The curcumin R-Ef% in the receptor compartment was higher at pH = 7.4 (18%- for the sample with a molar ratio of 0.25:1) than at pH = 5.5 (16.5%). The curcumin absorption in the skin membrane at pH = 5.5 (47%) was more intense than at pH = 7.4 (8.6%). The curcumin-loaded films' antioxidant activity was improved due to the CS presence.
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