期刊
MOLECULAR THERAPY
卷 29, 期 6, 页码 1946-1957出版社
CELL PRESS
DOI: 10.1016/j.ymthe.2021.04.020
关键词
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资金
- National Natural Science Foundation of China [81971143, 81900496]
- Qianjiang Talent Program of Zhejiang Province [QJD1902017]
- German Research Foundation [DFG-SFB 854-A30N]
Extracellular vesicles play a crucial role in intercellular communication in the central nervous system, influencing the pathogenesis and treatment of neuroinflammatory diseases.
Extracellular vesicles (EVs) are bilayer membrane vesicles and act as key messengers in intercellular communication. EVs can be secreted by both neurons and glial cells in the central nervous system (CNS). Under physiological conditions, EVs contribute to CNS homeostasis by facilitating omnidirectional communication among CNS cell populations. In response to CNS injury, EVs mediate neuroinflammatory responses and regulate tissue damage and repair, thereby influencing the pathogenesis, development, and/or recovery of neuroinflammatory diseases, including CNS autoimmune diseases, neurodegenerative diseases, stroke, CNS traumatic injury, and CNS infectious diseases. The unique ability of EVs to pass through the blood-brain barrier further confers them an important role in the bidirectional communication between the CNS and periphery, and application of EVs enables the diagnosis, prognosis, and therapy of neuroinflammatory diseases in a minimally invasive manner.
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