期刊
MOLECULAR PSYCHIATRY
卷 27, 期 1, 页码 710-730出版社
SPRINGERNATURE
DOI: 10.1038/s41380-021-01142-w
关键词
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资金
- Senior Research Fellowship (SRF B) from the National Health and Medical Research Council of Australia
- National Health and Medical Research Council of Australia [APP1146644]
- Australian Government Research Training Program (RTP) Scholarship
The high heritability of autism spectrum disorder (ASD) suggests a predominant role of genetics in its development; environmental exposures may also play a causal role in the emergence of deleterious de novo variations; further research is needed to determine the direct contribution of these factors to the ASD phenotype.
Although the full aetiology of autism spectrum disorder (ASD) is unknown, familial and twin studies demonstrate high heritability of 60-90%, indicating a predominant role of genetics in the development of the disorder. The genetic architecture of ASD consists of a complex array of rare and common variants of all classes of genetic variation usually acting additively to augment individual risk. The relative contribution of heredity in ASD persists despite selective pressures against the classic autistic phenotype; a phenomenon thought to be explained, in part, by the incidence of spontaneous (or de novo) mutations. Notably, environmental exposures attributed as salient risk factors for ASD may play a causal role in the emergence of deleterious de novo variations, with several ASD-associated agents having significant mutagenic potential. To explore this hypothesis, this review article assesses published epidemiological data with evidence derived from assays of mutagenicity, both in vivo and in vitro, to determine the likely role such agents may play in augmenting the genetic liability in ASD. Broadly, these exposures were observed to elicit genomic alterations through one or a combination of: (1) direct interaction with genetic material; (2) impaired DNA repair; or (3) oxidative DNA damage. However, the direct contribution of these factors to the ASD phenotype cannot be determined without further analysis. The development of comprehensive prospective birth cohorts in combination with genome sequencing is essential to forming a causal, mechanistic account of de novo mutations in ASD that links exposure, genotypic alterations, and phenotypic consequences.
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