期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 65, 期 11, 页码 -出版社
WILEY
DOI: 10.1002/mnfr.202001118
关键词
CD4(+)IL‐ 17A(+) helper T cells; Lycium barbarum polysaccharide; regulatory T cell; salivary gland; sjö gren' s syndrome
资金
- National Natural Science Foundation of China [82071813, 31530020]
- Ningxia Key Research and Development Program Grant
- Peking-Tsinghua Center for Life Sciences, Beijing sci-Tech Program [Z191100006619114]
- Clinical Medicine Plus X-Young scholars Project of Peking University by the Fundamental Research Funds for the Central Universities [PKU2020LCXQ018]
The study demonstrates that Lycium barbarum polysaccharide (LBP) inhibits the progression of primary Sjogren's syndrome (pSS) in mice by modulating T cell differentiation.
Scope This study aims to evaluate the therapeutic efficacy and mechanisms of Lycium barbarum polysaccharide (LBP) in primary Sjogren's syndrome (pSS). Methods and results Non-obese diabetic mice (the pSS model) are randomly divided into four groups: Low dose LBP (LBP.L, 5 mg kg(-1) d(-1)), high dose LBP (10 mg kg(-1) d(-1)), low dose interleukin (IL)-2 (25 000 IU/d), and control (saline water). Drugs were treated for 12 weeks. LBP.L significantly reduces the salivary gland inflammation compared with the control group (histological score p (LBP.L) vs (Control) = 0.019; foci number: p (LBP.L) vs (Control) = 0.038). LBP.L also remarkably reduces the effector follicular helper T (Tfh) cells and the CD4(+)IL-17A(+) helper T (Th17) cells in both spleen and cervical lymph node (cLN) cells. Additionally, the ratios of regulatory T cell (Treg)/Tfh cells and Treg/Th17 cells are substantially increased in mice treated with LBP.L in both spleen and cLNs. LBP also inhibits Th17 and Tfh cells and markedly increases the Treg/Tfh ratio in human peripheral blood mononuclear cells. Conclusion LBP.L inhibits the progression of pSS in mice, associated with modulation of T cell differentiation.
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