期刊
MOLECULAR NEUROBIOLOGY
卷 -, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1007/s12035-021-02427-5
关键词
Peroxiredoxin 6; Neuropsychiatric disorders; Knockdown; Overexpression
资金
- National Natural Science Foundation of China [81871068, 81671352, 91232709]
- Joint Fund for Science and Technology Innovation of Fujian [2018Y9057]
- Startup Fund for Scientific Research of Fujian Medical University [2019QH2014]
This review focuses on the essential roles of PRDX6 in neuropsychiatric disorders and suggests potential implications for developing pharmacological treatments and genetic therapies.
Peroxiredoxin 6 (PRDX6), the only mammalian 1-Cys member of the peroxiredoxins (PRDXs) family, has multiple functions of glutathione peroxidase (Gpx) activity, acidic calcium-independent phospholipase (aiPLA2) activity, and lysophosphatidylcholine acyl transferase (LPCAT) activity. It has been documented to be involved in redox homeostasis, phospholipid turnover, glycolipid metabolism, and cellular signaling. Here, we reviewed the characteristics of the available Prdx6 genetic mouse models and the research progresses made with regard to PRDX6 in neuropsychiatric disorders, including neurodegenerative diseases, brain aging, stroke, neurotrauma, gliomas, major depressive disorder, drug addiction, post-traumatic stress disorder, and schizophrenia. The present review highlights the important roles of PRDX6 in neuropsychiatric disorders and may provide novel insights for the development of effective pharmacological treatments and genetic therapies.
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