期刊
MOLECULAR MICROBIOLOGY
卷 116, 期 2, 页码 498-515出版社
WILEY
DOI: 10.1111/mmi.14728
关键词
Borrelia; cytokines; neutrophils; vascular transmigration
资金
- Canadian Institutes of Health Research [PJT-153336]
Lyme disease, caused by Borrelia burgdorferi, is the most common tick-transmitted disease in the northern hemisphere. The mechanism by which these spirochetes breach the blood vessel wall to reach distant tissues is not well understood. Research has revealed that host neutrophils play a role in promoting bacterial escape into surrounding tissue by producing specific cytokines.
Lyme disease is the most common tick-transmitted disease in the northern hemisphere and is caused by the spirochete Borrelia burgdorferi and related Borrelia species. The constellation of symptoms attributable to this malady results from vascular dissemination of B. burgdorferi throughout the body to invade various tissue types. However, little is known about the mechanism by which the spirochetes can breach the blood vessel wall to reach distant tissues. We have studied this process by direct observation of spirochetes in the microvasculature of living mice using multi-laser spinning-disk intravital microscopy. Our results show that in our experimental system, instead of phagocytizing B. burgdorferi, host neutrophils are involved in the production of specific cytokines that activate the endothelium and potentiate B. burgdorferi escape into the surrounding tissue. Spirochete escape is not induced by paracellular permeability and appears to occur via a transcellular pathway. Neutrophil repurposing to promote bacterial extravasation represents a new and innovative pathogenic strategy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据