4.7 Article

The effect of pedunculopontine nucleus deep brain stimulation on postural sway and vestibular perception

期刊

EUROPEAN JOURNAL OF NEUROLOGY
卷 23, 期 3, 页码 668-670

出版社

WILEY
DOI: 10.1111/ene.12947

关键词

balance; deep brain stimulation; sensory integration; sway; vision

资金

  1. Bupa Foundation
  2. Medical Research Council of the UK
  3. Academy of Medical Sciences
  4. Engineering and Physical Sciences Research Council [EP/K503381/1] Funding Source: researchfish
  5. Medical Research Council [G0701698] Funding Source: researchfish
  6. MRC [G0701698] Funding Source: UKRI

向作者/读者索取更多资源

Background and purposeDeep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) reduces the number of falls in patients with Parkinson's disease (PD). It was hypothesized that enhanced sensory processing contributes to this PPN-mediated gait improvement. MethodsFour PD patients (and eight matched controls) with implanted bilateral PPN and subthalamic nucleus DBS electrodes were assessed on postural (with/without vision) and vestibular perceptual threshold tasks. ResultsPedunculopontine nucleus ON stimulation (compared to OFF) lowered vestibular perceptual thresholds but there was a disproportionate increase in the normal sway increase on going from light to dark. ConclusionsThe disproportionate increased sway with PPN stimulation in the dark may paradoxically improve balance function since mechanoreceptor signals rapidly adapt to continuous pressure stimulation from postural akinesia. Additionally, the PPN-mediated vestibular signal enhancement also improves the monitoring of postural sway. Overall, PPN stimulation may improve sensory feedback and hence balance performance.

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