Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis

Huang et al. (2021) identified a mechanism acting through the arginine methyltransferase PRMT6 that stabilizes the interaction of RCC1 with chromatin, promoting cell proliferation and tumorigenicity. Targeting this mechanism might enhance the treatment of tumors such as glioblastoma.

Automated summary

The mechanism identified by Huang et al. stabilizes the interaction of RCC1 with chromatin through the arginine methyltransferase PRMT6, promoting cell proliferation and tumor formation. Targeting this mechanism may improve the treatment of tumors such as glioblastoma.