4.8 Editorial Material

K29/K48-branched ubiquitin chains TRIP the alarm fueling neo-substrate degradation via the CRL2VHL

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Summary: The study reveals that the ubiquitin ligase TRIP12 and K29/K48-branched ubiquitin chains play crucial roles in targeted protein degradation, accelerating the degradation process induced by PROTACs. This cooperative mechanism is unique and enhances the efficiency of degrading neo-substrates.

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