期刊
MOLECULAR CANCER
卷 20, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12943-021-01365-z
关键词
Gastric cancer; Small extracellular vesicles; Exosomes; Diagnosis; Therapy; Molecular mechanism
资金
- Key Research and Development Program of Shandong Province [2019JZZY010104, 2019GSF108146]
- Special Foundation for Taishan Scholars Program of Shandong Province
- Academic promotion programme of Shandong First Medical University [2019QL021]
sEVs, especially exosomes, play crucial roles in GC by influencing the tumor microenvironment, cell-to-cell communication, and immunotherapeutic efficacy, showing potential clinical applications in the future.
Gastric cancer (GC) is a common tumour that affects humans worldwide, is highly malignant and has a poor prognosis. Small extracellular vesicles (sEVs), especially exosomes, are nanoscale vesicles released by various cells that deliver bioactive molecules to recipient cells, affecting their biological characteristics, changing the tumour microenvironment and producing long-distance effects. In recent years, many studies have clarified the mechanisms by which sEVs function with regard to the initiation, progression, angiogenesis, metastasis and chemoresistance of GC. These molecules can function as mediators of cell-cell communication in the tumour microenvironment and might affect the efficacy of immunotherapy. Due to their unique physiochemical characteristics, sEVs show potential as effective antitumour vaccines as well as drug carriers. In this review, we summarize the roles of sEVs in GC and highlight the clinical application prospects in the future.
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