Long noncoding RNAs as a piece of polycystic ovary syndrome puzzle

Polycystic ovary syndrome (PCOS) is an endocrine disorder and affects 5-10% of reproductive-age women. Chronic anovulation, polycystic ovaries, and hyperandrogenism are the important features of this syndrome. Furthermore, hyperinsulinemia and central obesity are frequent in PCOS women. In recent years, noncoding RNAs detection provided new ideas to explain the etiology of female reproductive disorders. Long noncoding RNAs (lncRNAs) as a subset of noncoding RNAs are associated with the pathogenesis of manifold reproductive-related disorders. Various investigations emphasized the potential involvement of lncRNAs in PCOS development. Therefore, in this paper, we will summarize the function of numerous lncRNAs in the apoptosis and proliferation of granulosa cells (GCs), insulin resistance (IR), and steroidogenesis in PCOS.

Automated summary

PCOS is an endocrine disorder that affects 5-10% of reproductive-age women, characterized by chronic anovulation, polycystic ovaries, hyperandrogenism, hyperinsulinemia, and central obesity. Recent research has highlighted the potential involvement of long noncoding RNAs in the development of PCOS.