期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 38, 期 9, 页码 3676-3680出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msab134
关键词
Bos grunniens; reference genome; domestication; structural variants
资金
- Second Tibetan Plateau Scientific Expedition and Research (STEP) program [2019QZKK0502]
- national youth talent support program
- National Natural Science Foundation of China [31661143020, 41620104007]
- Fundamental Research Funds for the Central Universities [lzujbky2019]
- International Collaboration 111 Programme [BP0719040]
This study presents a chromosome-scale reference genome for domestic yaks and identifies a large number of structural variants (SVs) that contain repetitive DNA sequences, with some located near genes. By comparing SVs in domestic and wild yaks, genes related to the nervous system, behavior, immunity, and reproduction were found to have potentially been targeted by artificial selection during yak domestication, providing new insights into the domestication of high-altitude animals.
Structural variants (SVs) represent an important genetic resource for both natural and artificial selection. Here we present a chromosome-scale reference genome for domestic yak (Bos grunniens) that has longer contigs and scaffolds (N50 44.72 and 114.39 Mb, respectively) than reported for any other ruminant genome. We further obtained long-read resequencing data for 6 wild and 23 domestic yaks and constructed a genetic SV map of 372,220 SVs that covers the geographic range of the yaks. The majority of the SVs contains repetitive sequences and several are in or near genes. By comparing SVs in domestic and wild yaks, we identified genes that are predominantly related to the nervous system, behavior, immunity, and reproduction and may have been targeted by artificial selection during yak domestication. These findings provide new insights in the domestication of animals living at high altitude and highlight the importance of SVs in animal domestication.
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