相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。IGF-1R pathway activation as putative biomarker for linsitinib therapy to revert tamoxifen resistance in ER-positive breast cancer
Dinja T. Kruger et al.
INTERNATIONAL JOURNAL OF CANCER (2020)
RNA-binding protein CUGBP1 controls the differential INSR splicing in molecular subtypes of breast cancer cells and affects cell aggressiveness
Gena Huang et al.
CARCINOGENESIS (2020)
Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, and breast cancer risk: observational and Mendelian randomization analyses with ∼ 430 000 women
N. Murphy et al.
ANNALS OF ONCOLOGY (2020)
IGF1R constitutive activation expands luminal progenitors and influences lineage differentiation during breast tumorigenesis
Susan M. Farabaugh et al.
DEVELOPMENTAL BIOLOGY (2020)
Circulating Insulin-Like Growth Factor-1 and Risk of Total and 19 Site-Specific Cancers: Cohort Study Analyses from the UK Biobank
Frank Qian et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2020)
Fasting-mimicking diet and hormone therapy induce breast cancer regression
Irene Caffa et al.
NATURE (2020)
Fasting mimicking diet as an adjunct toneoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial
Stefanie de Groot et al.
NATURE COMMUNICATIONS (2020)
Insulin resistance contributes to racial disparities in breast cancer prognosis in US women
Emily J. Gallagher et al.
BREAST CANCER RESEARCH (2020)
Update on triple-negative breast cancer disparities for the United States: A population-based study from the United States Cancer Statistics database, 2010 through 2014
Lia C. Scott et al.
CANCER (2019)
Thirty sweet years of GLUT4
Amira Klip et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Metastatic Breast Carcinoma-Associated Fibroblasts Have Enhanced Protumorigenic Properties Related to Increased IGF2 Expression
Yirui Gui et al.
CLINICAL CANCER RESEARCH (2019)
Paracrine recruitment and activation of fibroblasts by c-Myc expressing breast epithelial cells through the IGFs/IGF-1R axis
Anna De Vincenzo et al.
INTERNATIONAL JOURNAL OF CANCER (2019)
Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2
Jose Mercado-Matos et al.
MOLECULAR AND CELLULAR BIOLOGY (2018)
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
Benjamin D. Hopkins et al.
NATURE (2018)
Fasting and cancer: molecular mechanisms and clinical application
Alessio Nencioni et al.
NATURE REVIEWS CANCER (2018)
IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma
Sha Zhu et al.
JCI INSIGHT (2018)
Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells
K. Tominaga et al.
ONCOGENE (2017)
Combined and individual tumor-specific expression of insulin-like growth factor-I receptor, insulin receptor and phospho-insulin-like growth factor-I receptor/insulin receptor in primary breast cancer: Implications for prognosis in different treatment groups
Sofie Bjorner et al.
ONCOTARGET (2017)
Insulin Receptor Isoforms in Physiology and Disease: An Updated View
Antonino Belfiore et al.
ENDOCRINE REVIEWS (2017)
Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells
Jose Mercado-Matos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
Weikang Cai et al.
NATURE COMMUNICATIONS (2017)
Clinical and Translational Results of a Phase II, Randomized Trial of an Anti-IGF-1R (Cixutumumab) in Women with Breast Cancer That Progressed on Endocrine Therapy
William J. Gradishar et al.
CLINICAL CANCER RESEARCH (2016)
Metabolic syndrome and pre-diabetes contribute to racial disparities in breast cancer outcomes: hypothesis and proposed pathways
Emily J. Gallagher et al.
DIABETES-METABOLISM RESEARCH AND REVIEWS (2016)
Pretreatment Insulin Levels as a Prognostic Factor for Breast Cancer Progression
Patrizia Ferroni et al.
ONCOLOGIST (2016)
CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy
Ran Rostoker et al.
BREAST CANCER RESEARCH (2016)
Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer
Michael D. Brooks et al.
CELL STEM CELL (2015)
Highly specific role of the insulin receptor in breast cancer progression
Ran Rostoker et al.
ENDOCRINE-RELATED CANCER (2015)
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells
Devon A. Lawson et al.
NATURE (2015)
Obesity and cancer, a case for insulin signaling
Y. Poloz et al.
CELL DEATH & DISEASE (2015)
Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity
Toshiaki Fukushima et al.
NATURE COMMUNICATIONS (2015)
Role of IGF1R in breast cancer subtypes, sternness, and lineage differentiation
Susan M. Farabaugh et al.
FRONTIERS IN ENDOCRINOLOGY (2015)
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
Lauren M. Thorpe et al.
NATURE REVIEWS CANCER (2015)
IGF1R Inhibition in Mammary Epithelia Promotes Canonical Wnt Signaling and Wnt1-Driven Tumors
Lauren M. Rota et al.
CANCER RESEARCH (2014)
Can we unlock the potential of IGF-1R inhibition in cancer therapy?
Helen King et al.
CANCER TREATMENT REVIEWS (2014)
Insulin Receptor Substrate 2-mediated Phosphatidylinositol 3-kinase Signaling Selectively Inhibits Glycogen Synthase Kinase 3β to Regulate Aerobic Glycolysis
Justine Landis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
IGF binding proteins in cancer: mechanistic and clinical insights
Robert C. Baxter
NATURE REVIEWS CANCER (2014)
IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumors
Holly A. Porter et al.
CANCER LETTERS (2013)
Therapeutic Destruction of Insulin Receptor Substrates for Cancer Treatment
Hadas Reuveni et al.
CANCER RESEARCH (2013)
The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors
Wen-Wei Chang et al.
BREAST CANCER RESEARCH (2013)
Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs
Hidehito Yoshihara et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes
Rinat Yerushalmi et al.
BREAST CANCER RESEARCH AND TREATMENT (2012)
The Insulin Receptor/Insulin-Like Growth Factor Receptor Family as a Therapeutic Target in Oncology
Michael Pollak
CLINICAL CANCER RESEARCH (2012)
Insulinemia and the risk of breast cancer and its relapse
V. Formica et al.
DIABETES OBESITY & METABOLISM (2012)
Quantifying insulin receptor isoform expression in FFPE breast tumors
Sean C. Harrington et al.
GROWTH HORMONE & IGF RESEARCH (2012)
Targeting Insulin and Insulin-Like Growth Factor Signaling in Breast Cancer
Yuzhe Yang et al.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2012)
Membrane localization of insulin receptor substrate-2 (IRS-2) is associated with decreased overall survival in breast cancer
Jennifer L. Clark et al.
BREAST CANCER RESEARCH AND TREATMENT (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti-IGF-IR Therapy
Beate C. Litzenburger et al.
CLINICAL CANCER RESEARCH (2011)
Decreased IGF Type 1 Receptor Signaling in Mammary Epithelium during Pregnancy Leads to Reduced Proliferation, Alveolar Differentiation, and Expression of Insulin Receptor Substrate (IRS)-1 and IRS-2
Zhaoyu Sun et al.
ENDOCRINOLOGY (2011)
Diabetes Mellitus and Breast Cancer Outcomes: A Systematic Review and Meta-Analysis
Kimberly S. Peairs et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Nuclear IRS-1 predicts tamoxifen response in patients with early breast cancer
Ilenia Migliaccio et al.
BREAST CANCER RESEARCH AND TREATMENT (2010)
Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes
Ruslan Novosyadlyy et al.
CANCER RESEARCH (2010)
Differential insulin-like growth factor II (IGF-II) expression: A potential role for breast cancer survival disparity
S. Kalla Singh et al.
GROWTH HORMONE & IGF RESEARCH (2010)
Prolonged Drug Selection of Breast Cancer Cells and Enrichment of Cancer Stem Cell Characteristics
Anna Maria Calcagno et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2010)
The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival
D. Sachdev et al.
ONCOGENE (2010)
Insulin receptor substrate 1 modulates the transcriptional activity and the stability of androgen receptor in breast cancer cells
Marilena Lanzino et al.
BREAST CANCER RESEARCH AND TREATMENT (2009)
Hypoxia Regulates Insulin Receptor Substrate-2 Expression to Promote Breast Carcinoma Cell Survival and Invasion
Katerina Mardilovich et al.
CANCER RESEARCH (2009)
Expression and function of the insulin receptor substrate proteins in cancer
Katerina Mardilovich et al.
CELL COMMUNICATION AND SIGNALING (2009)
Growth Hormone and Insulin-Like Growth Factor-I in the Transition from Normal Mammary Development to Preneoplastic Mammary Lesions
David L. Kleinberg et al.
ENDOCRINE REVIEWS (2009)
Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease
Antonino Belfiore et al.
ENDOCRINE REVIEWS (2009)
Insulin Receptor Substrate-2 Regulates Aerobic Glycolysis in Mouse Mammary Tumor Cells via Glucose Transporter 1
Shannon L. Pankratz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The Phosphotyrosine Interactome of the Insulin Receptor Family and Its Substrates IRS-1 and IRS-2
Stefan Hanke et al.
MOLECULAR & CELLULAR PROTEOMICS (2009)
Keeping IGF-II under control: Lessons from the IGF-II-IGF2R crystal structure
James Brown et al.
TRENDS IN BIOCHEMICAL SCIENCES (2009)
Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival
Jennifer H. Law et al.
CANCER RESEARCH (2008)
Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis
Chad J. Creighton et al.
JOURNAL OF CLINICAL ONCOLOGY (2008)
Nuclear insulin receptor substrate-1 activates promoters of cell cycle progression genes
A. Wu et al.
ONCOGENE (2008)
Insulin and insulin-like growth factor signalling in neoplasia
Michael Pollak
NATURE REVIEWS CANCER (2008)
Enhanced sensitivity to IGF-II signalling links loss of imprinting of IGF2 to increased cell proliferation and tumour risk
Atsushi Kaneda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
Jiandi Zhang
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Insulin-like growth factor type-I receptor internalization and recycling mediate the sustained phosphorylation of Akt
Robert J. Romanelli et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Expression of nuclear insulin receptor substrate 1 in breast cancer
Diego Sisci et al.
JOURNAL OF CLINICAL PATHOLOGY (2007)
Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis
Shannon L. Gibson et al.
CELL CYCLE (2007)
The prognostic role of a gene signature from tumorigenic breast-cancer cells.
Rui Liu et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis
Zhefu Ma et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells
S. A. Byron et al.
BRITISH JOURNAL OF CANCER (2006)
RNAi-mediated silencing of insulin receptor substrate 1 (IRS-1) enhances tamoxifen-induced cell death in MCF-7 breast cancer cells
G Cesarone et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2006)
Epidermal growth factor induces insulin receptor substrate-2 in breast cancer cells via c-Jun NH2-terminal kinase/activator protein-1 signaling to regulate cell migration
Xiaojiang Cui et al.
CANCER RESEARCH (2006)
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
KE O'Reilly et al.
CANCER RESEARCH (2006)
In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417
P Haluska et al.
CANCER RESEARCH (2006)
Molecular links between obesity and breast cancer
A. M. Lorincz et al.
ENDOCRINE-RELATED CANCER (2006)
Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and β-catenin
J Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
P Gual et al.
BIOCHIMIE (2005)
A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells
D Sachdev et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Nuclear insulin receptor substrate 1 interacts with estrogen receptor α at ERE promoters
C Morelli et al.
ONCOGENE (2004)
Expression of insulin-like growth factor 1 receptor in primary breast cancer: Immunohistochemical analysis
C Shimizu et al.
HUMAN PATHOLOGY (2004)
Postmenopausal levels of oestrogen, androgen, and SHBG and breast cancer: long-term results of a prospective study
A Zeleniuch-Jacquotte et al.
BRITISH JOURNAL OF CANCER (2004)
Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression
XH Zhang et al.
BREAST CANCER RESEARCH AND TREATMENT (2004)
Involvement of insulin receptor substrate 2 in mammary tumor metastasis
JA Nagle et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
Christina Kaiser et al.
BMC BIOLOGY (2004)
Insulin/IGF-I-signaling pathway:: an evolutionarily conserved mechanism of longevity from yeast to humans
M Barbieri et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)
Progesterone crosstalks with insulin-like growth factor signaling in breast cancer cells via induction of insulin receptor substrate-2
XJ Cui et al.
ONCOGENE (2003)
Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
M Schubert et al.
JOURNAL OF NEUROSCIENCE (2003)
Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland
AV Lee et al.
ENDOCRINOLOGY (2003)
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults
EE Calle et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans
M Björnholm et al.
DIABETOLOGIA (2002)
Structural biology of insulin and IGF1 receptors: Implications for drug design
P De Meyts et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
IRS proteins and the common path to diabetes
MF White
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2002)
Synergistic proliferative action of insulin-like growth factor I and 17 β-estradiol in MCF-7S breast tumor cells
IHL Hamelers et al.
EXPERIMENTAL CELL RESEARCH (2002)
Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines
JG Jackson et al.
ONCOGENE (2001)
Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2
LY Rui et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Functional inactivation, of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes
AM Fernández et al.
GENES & DEVELOPMENT (2001)
Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3 '-kinase inhibition
AV Lee et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis
VR Fantin et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2000)
分享论文
