期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 528, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2021.111258
关键词
Adrenal; Medulla; Cortex; Development; Interactions; Stem cells; Pathologies
资金
- Deutsche Forschungsgemeinschaft (DFG, German Research foundation) [314061271, TRR 205/1, 288034826, IRTG 2251]
The mammalian adrenal gland is composed of the medulla and cortex, which interact closely during development and are important for proper differentiation and function of the gland. Interfaces between the two parts are common in tumor development.
The mammalian adrenal gland is composed of two distinct tissue types in a bidirectional connection, the catecholamine-producing medulla derived from the neural crest and the mesoderm-derived cortex producing steroids. The medulla mainly consists of chromaffin cells derived from multipotent nerve-associated descendants of Schwann cell precursors. Already during adrenal organogenesis, close interactions between cortex and medulla are necessary for proper differentiation and morphogenesis of the gland. Moreover, communication between the cortex and the medulla ensures a regular function of the adult adrenal. In tumor development, interfaces between the two parts are also common. Here, we summarize the development of the mammalian adrenal medulla and the current understanding of the cortical-medullary interactions under development and in health and disease.
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