期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 22, 期 2, 页码 312-321出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557521666210505112834
关键词
Astaxanthin; oxidative stress; cardioprotective; neuroprotective; Nrf2 signaling pathway; renoprotective; diabetes mellitus
Astaxanthin, a naturally occurring compound, has various beneficial activities including antioxidant, anti-inflammatory, and anti-tumor effects. Although the exact protective mechanisms are unclear, the Nrf2 signaling pathway may play a critical role in these effects.
Astaxanthin (AST) is a naturally occurring compound isolated from various sources such as fungi, plants, salmon, and crab. However, Haematococcus Pluvialis, a green alga, is the primary source of this beta carotenoid compound. AST has several favourable biological and pharmacological activities such as antioxidant, anti-inflammatory, anti-tumor, anti-diabetes, hepatoprotective, and neuroprotective activities. Nevertheless, the exact molecular mechanisms of these protective effects of AST are unclear yet. The Nrf2 signaling pathway is one of the critical candidate signaling pathways that may be involved in these beneficial effects of AST. This signaling pathway is responsible for maintaining the redox balance in the physiological state. Upon nuclear translocation, Nrf2 signaling activates antioxidant enzymes to reduce oxidative stress and protect cells against damage. In the current study, we have reviewed the effects of AST on the Nrf2 signaling pathway, which could potentially be developed as a novel therapeutic approach for the management of various diseases.
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