期刊
MICROBES AND INFECTION
卷 23, 期 6-7, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.micinf.2021.104815
关键词
Microbiome; Microbial biogeography; Community dynamics; Intestinal pathogenesis; Intestinal mucus
资金
- CIHR Team Grant: Canadian Microbiome Initiative 2 [FASF1904421]
- Crohn's and Colitis Canada [22R04462]
- NSERC [PGS-D 6564]
- UBC Four Year Fellowship [6456]
- CIFAR [GS20011]
- Michael Smith Foundation for Health Research Scholar Award [18239]
The review discusses the differences in microbial organization in the human gut between health and disease states, and how changes in spatial organization can impact gut homeostasis. It concludes by looking towards future research to uncover causality.
The human gut hosts a dense and diverse microbial community, spatially organized in multiple scales of structure. Here, we review how microbial organization differs between health and disease. We describe how changes in spatial organization may induce alterations in gut homeostasis, concluding with a future outlook to reveal causality. (c) 2021 The Author(s). Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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