期刊
METHODS
卷 196, 期 -, 页码 36-46出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2021.04.014
关键词
Circular RNAs (circRNAs); RNA-binding proteins (RBPs); Ribonucleoprotein complexes (RNPs); RNA-protein interactions
资金
- Deutsche Forschungsgemeinschaft [RTG 2355, Bi 316/18-1, SPP 1935, Bi 316/20-1, FOR 5116]
- Cardio-Pulmonary Institute (CPI) within the Excellence Strategy Program [Exc 2026]
- State of Hessen
- LOEWE Centre DRUID [E2]
CircRNAs have been extensively studied in recent years, revealing functional roles in various cell types and organisms. However, the specific interaction partners for most circRNAs remain unknown due to technical difficulties, presenting challenges in systematically studying circRNA-protein complexes.
Circular RNAs (circRNAs) have been studied extensively in the last few years, uncovering functional roles in a diverse range of cell types and organisms. As shown for a few cases, these functions may be mediated by trans- acting factors, in particular RNA-binding proteins (RBPs). However, the specific interaction partners for most circRNAs remain unknown. This is mainly due to technical difficulties in their identification and in differentiating between interactors of circRNAs and their linear counterparts. Here we review the currently used methodology to systematically study circRNA-protein complexes (circRNPs), focusing either on a specific RNA or protein, both on the gene-specific or global level, and discuss advantages and challenges of the available approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据