Relationship between HLA-DRB1 gene polymorphism and breast cancer A protocol for systematic review and meta-analysis

Background: Breast cancer is one of the common malignant tumors in women, which seriously affects women's physical and mental health and even life-threatening. The occurrence and development of breast cancer are closely related to genetic factors. Many studies have shown that human leukocyte antigen DRB1 is associated with the development of breast cancer, but lack evidence. This study aims to systematically evaluate the relationship between HLA-DRB1 gene polymorphism and breast cancer. Methods: The retrieval time of this study was from the establishment of the database to February 2021. The retrieval databases included CNKI, Wanfang, VIP and China Biomedical Database, PubMed, Embase, Web of Science, and the Cochrane Library. The retrieval objects were observational studies on the relationship between HLA-DRB1 gene polymorphism and breast cancer (including case--control studies, cross-sectional studies, and cohort studies). The language restrictions were English and Chinese. Two researchers independently extracted the data and assessed the quality of the included studies, and Stata 16.0 software was used for statistical analysis. Results: This study will systematically evaluate the relationship between HLA-DRB1 gene polymorphism and breast cancer based on existing studies. Conclusion: This study will explore the early warning signal of breast cancer genetic susceptibility, and provide evidence-based medical evidence for clarifying the role of HLA-DRB1 gene polymorphism in breast cancer. OSF Registration number: DOI 10.17605/OSF.IO/847FQ

Automated summary

This study aims to explore the relationship between HLA-DRB1 gene polymorphism and breast cancer, providing evidence-based support. The study utilized systematic evaluation methods, searched multiple databases, and selected relevant studies. Two researchers independently conducted data extraction and quality assessment, and ultimately performed data analysis using statistical software.