Predictive role of the modified Glasgow prognostic score for in-hospital mortality in stable acute pulmonary embolism

Background and importance: The modified Glasgow prognostic score (mGPS) has been reported to have a prognostic value in various patient populations. However, the prognostic significance of mGPS has not been studied inacute pulmonary embolism (APE). Objective: This study aimed to investigate the predictive value of mGPS on in-hospital mortality in patients with hemodynamically stableAPE. Methods: We retrospectively included 258 hemodynamically stableAPE patients. Clinical, echocardiographic, and laboratory data recorded on admission. The mGPS scored as 0, 1, or 2 based on the C-reactive protein (CRP) and albumin levels. Results: A total of 258hemodynamically stableAPE patients were included, and 28 (10.9%) died during the hospital stay. Compared with survivors, non-survivors were older, had higher N-terminal pro-B-type natriuretic peptide, CRP, creatinine, high-sensitive cardiac troponin T (hs-cTnT), and mGPS levels, and had higher pulmonary embolism severity index (PESI) at study entry. In the multivariate logistic regression analysis, NT-proBNP > 2350 pg/mL (OR: 2.180, 95% CI 1.102-5.213, p < 0.001), hs-cTnT > 21 pg/mL (OR: 1.426, 95% CI 1.151-3.751, p = 0.001), CRP > 3.1 mg/dL (OR: 1.567, 95% CI 1.072-4.429, p = 0.001), PESI > 139 (OR: 2.745, 95% CI 1.869-6.369, p = 0.001), systolic blood pressure < 100 mmHg (OR: 3.465, 95% CI 1.867-8.934, p < 0.001), mGPS = 1 (OR: 2.120, 95% CI 1.089-3.754, p = 0.011), and mGPS = 2 (OR: 3.350, 95% CI 1.457-5.367, p < 0.001) were independently associated with in-hospital mortality. Conclusion: This study demonstrates the mGPS, which is a new and easily measurable marker, is a useful predictor in-hospital mortality in hemodynamically stableAPE. (c) 2021 Elsevier Espan tilde a, S.L.U. All rights reserved.

Automated summary

This study investigates the predictive value of mGPS on in-hospital mortality in hemodynamically stable APE patients. The results demonstrate that mGPS is an independent predictor of in-hospital mortality and can be used as a useful marker in these patients.