期刊
MEDICAL ONCOLOGY
卷 38, 期 5, 页码 -出版社
HUMANA PRESS INC
DOI: 10.1007/s12032-021-01494-x
关键词
Prostate cancer; KIFC1; Centrosome clustering; Ploidy; Kinesins; Poly-aneuploid cancer cells
类别
资金
- Nanotechnology for Cancer Research Program at Johns Hopkins
- US Department of Defense CDMRP/PCRP [W81XWH-20-10353]
- Patrick C. Walsh Prostate Cancer Research Fund
- Prostate Cancer Foundation
- NCI [U54CA143803, CA163124, CA093900, CA143055]
- William and Carolyn Stutt Research Fund
- MC Dean, Inc.
- Jones Family Foundation
High expression of KIFC1 in prostate cancer is associated with poor clinical outcomes, including high Gleason score, advanced tumor stage, metastasis, and lower recurrence-free survival.
Kinesins play important roles in the progression and development of cancer. Kinesin family member C1 (KIFC1), a minus end-directed motor protein, is a novel Kinesin involved in the clustering of excess centrosomes found in cancer cells. Recently KIFC1 has shown to play a role in the progression of many different cancers, however, the involvement of KIFC1 in the progression of prostate cancer (PCa) is still not well understood. This study investigated the expression and clinical significance of KIFC1 in PCa by utilizing multiple publicly available datasets to analyze KIFC1 expression in patient samples. High KIFC1 expression was found to be associated with high Gleason score, high tumor stage, metastatic lesions, high ploidy levels, and lower recurrence-free survival. These results reveal that high KIFC1 levels are associated with a poor prognosis for PCa patients and could act as a prognostic indicator for PCa patients as well.
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