期刊
MEDICAL IMAGE ANALYSIS
卷 70, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.media.2021.102009
关键词
Alzheimer's disease (AD); Hyperbolic space; Ring-shaped patches; Sparse coding; Classification
类别
资金
- National Institutes of Health [RF1AG051710, R21AG065942, R01EB025032, U54EB020403, R01AG031581, P30AG19610]
- National Science Foundation [IIS1421165]
- Arizona Alzheimer's Consortium
- DOD ADNI (Department of Defense) [W81XWH-12-2-0012]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health ) [U01 AG024904]
- AbbVie
- Alzheimers Association
- Alzheimers Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc.
- Biogen
- Bristol-Myers Squibb Company
- CereSpir, Inc.
- Cogstate
- Eisai Inc.
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- EuroImmun
- F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.
- Fujirebio
- GE Healthcare
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research AMP
- Development, LLC.
- Johnson AMP
- Johnson harmaceutical Research AMP
- Development LLC.
- Lumosity
- Lundbeck
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC.
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- Canadian Institutes of Health Research
Hyperbolic geometry is applied in brain cortical and subcortical surfaces modeling, with a novel framework called hyperbolic stochastic coding (HSC) proposed for feature dimension reduction. By introducing feature extraction and max-pool algorithms in hyperbolic parameter space, the method shows superior classification accuracy in Alzheimer's disease progression studies.
Hyperbolic geometry has been successfully applied in modeling brain cortical and subcortical surfaces with general topological structures. However, such approaches, similar to other surface-based brain morphology analysis methods, usually generate high dimensional features. It limits their statistical power in cognitive decline prediction research, especially in datasets with limited subject numbers. To address the above limitation, we propose a novel framework termed as hyperbolic stochastic coding (HSC). We first compute diffeomorphic maps between general topological surfaces by mapping them to a canonical hyperbolic parameter space with consistent boundary conditions and extracts critical shape features. Secondly, in the hyperbolic parameter space, we introduce a farthest point sampling with breadth-first search method to obtain ring-shaped patches. Thirdly, stochastic coordinate coding and max-pooling algorithms are adopted for feature dimension reduction. We further validate the proposed system by comparing its classification accuracy with some other methods on two brain imaging datasets for Alzheimer's disease (AD) progression studies. Our preliminary experimental results show that our algorithm achieves superior results on various classification tasks. Our work may enrich surface-based brain imaging research tools and potentially result in a diagnostic and prognostic indicator to be useful in individualized treatment strategies. (c) 2021 Elsevier B.V. All rights reserved.
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