期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 195, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2021.111452
关键词
Adult hippocampal neurogenesis; Tau protein; Amyloid precursor protein; Apolipoprotein E; Alzheimer' s disease
资金
- National Nature Science Foundation for Young Scholars of China [81200834]
- Shenyang Science and Technology Program [20-205-4-090]
Alzheimer's disease is the most common cause of dementia globally, and the progression of neurodegeneration in the adult hippocampus is affected in AD. However, the exact molecular mechanisms are still unclear and further research is needed.
Alzheimer?s disease (AD) is the most common cause of dementia globally. AD is a progressive neurodegenerative disorder, eventually manifesting as severe cognitive impairment. Adult hippocampal neurogenesis (AHN) occurs throughout adulthood and plays an important role in hippocampus-dependent learning and memory. The stages of AHN, predominantly comprising the proliferation, differentiation, survival, and maturation of newborn neurons, are affected to varying degrees in AD. However, the exact molecular mechanisms remain to be elucidated. Recent evidence suggests that the molecules involved in AD pathology contribute to the compromised AHN in AD. Notably, various interventions may have common signaling pathways that, once identified, could be harnessed to enhance adult neurogenesis. This in turn could putatively rescue cognitive deficits associated with impaired neurogenesis as observed in animal models of AD. In this manuscript, we review the current knowledge concerning AHN under normal physiological and AD pathological conditions and highlight the possible role of specific molecules in AHN alteration in AD. In addition, we summarize in vivo experiments with emphasis on the effect of the activation of certain key signalings on AHN in AD rodent models. We propose that these signaling targets and corresponding interventions should be considered when developing novel therapies for AD.
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