期刊
MATURITAS
卷 147, 期 -, 页码 7-13出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.maturitas.2021.02.006
关键词
Senescence; Geroscience; Immunosenescence; Inflammaging; Aging
资金
- Australian Government through RTP training scholarships
- University of Melbourne PhD Stipend
- Victoria University PhD Stipend
- Immunology and Translational Research Group within the Institute for Health and Sport, Victoria University Australia
Cellular senescence is a critical part of human anti-tumor defence, but the accumulation of senescent cells with age can lead to various pathologies. Immunosenescence, the senescent change in immune cells, has a wide range of physiological effects and is partially responsible for many diseases associated with aging. Understanding the effects and mechanisms of immunosenescence can improve disease outcomes and prevention in older adults, and lead to new treatments for common illnesses.
Cellular senescence is a critical part of human anti-tumor defence; however, the accumulation of senescent cells with age underpins a wide range of pathologies. Senescent change in immune cells, or immunosenescence, has a wide range of physiological effects and is at least partially responsible for many diseases associated with aging. Immunosenescence underpins inflammaging, increased vulnerability to infectious disease with age, malignant change in the elderly, and auto-immunity. Understanding the effects and mechanisms of immunosenescence will improve disease outcomes and prevention in older adults, and generate new treatments for common illnesses. In this review we summarize the key changes occurring in immunosenescence across each facet of the immune system, and identify their clinical correlates.
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