期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2021.112190
关键词
Au nanobipyramids; Tumor targeting; Fluorescence imaging; Magnetic resonance imaging; Photothermal therapy
资金
- National Natural Science Foundation of China [81901798, 81771904]
- Natural Science Fund for Colleges and Universities in Jiangsu Province [19KJB310025]
- Startup Fund for Youth Talent in Xuzhou Medical University [D2019022]
- Science and Technology Development Program of Xuzhou [KC19141]
- Project Foundation of Jiangsu Graduate Research and Practice Innovation Program [SJCX20_0925]
A novel theranostic nanoplatform was developed by coupling prepared Au nanobipyramids with Gd2O3, Au nanoclusters and denatured bovine serum albumin (AuNBP-Gd2O3/Au-dBSA). The platform, conjugated with AS1411 aptamers, demonstrated specific tumor diagnosis and guidance of therapy through multimodal imaging. Additionally, the nanoparticles exhibited excellent photothermal anticancer effect with low toxicity in both in vitro and in vivo tests.
Multifunctional nanodrugs have emerged as an effective platform to integrate multiple imaging and therapeutic functions for tremendous biomedical applications. However, the development of a simple potent theranostic nanoplatform is still an intractable challenge. Herein, a novel theranostic nanoplatform was developed by coupling prepared Au nanobipyramids with Gd2O3, Au nanoclusters and denatured bovine serum albumin (AuNBP-Gd2O3/Au-dBSA) for FL/MR dual-modal imaging guided photothermal therapy. AS1411 aptamers were conjugated to enhance its targetability towards breast cancer. The AS1411-AuNBP-Gd2O3/Au-dBSA suspension could be readily heated above 40 degrees C at a low concentration (2 mg/L) and NIR density (1 W/cm(2)). The AS1411AuNBP-Gd2O3/Au-dBSA revealed a fluorescence quantum yield of 4.2% and higher longitudinal relaxivity rate of 6.75 mM-1 s-1 compared to Gd-DTPA of 4.45 mM-1 s-1. As a result, the AS1411-AuNBP-Gd2O3/Au-dBSA functions as a multimodal nanoprobe of photothermal, fluorescence and MR imaging for specific tumor diagnosis and guidance of therapy, which was validated via in vitro and in vivo tests. Moreover, AS1411-AuNBP-Gd2O3/AudBSA nanoparticles indicated excellent photothermal anticancer effect more than 95% in both in vitro and in vivo tests. Besides, the low toxicity of AS1411-AuNBP-Gd2O3/Au-dBSA nanocomposites was further confirmed in vitro and in vivo. Thus, these results demonstrated the AS1411-AuNBP-Gd2O3/Au-dBSA nanocomposites as a rational design of multifunctional nanoplatform to enable multimodal imaging guided photothermal therapy.
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