期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 110, 期 -, 页码 13-31出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2015.12.017
关键词
N-substituted pyrrole; Fused pyrroles; Natural pyrrole derivatives; Therapeutic agents
资金
- UGC, New Delhi
Pyrrole derivatives comprise a class of biologically active heterocyclic compounds which can serve as promising scaffolds for antimicrobial, antiviral, antimalarial, antitubercular, anti-inflammatory and enzyme inhibiting drugs. Due to their inimitable anticancer and anti-tubercular properties, researchers were inspired to develop novel pyrrole derivatives for the treatment of MDR pathogens. In the present review the main target is to focus on the development of pyrrole mimics, with emphasis based on their structure activity relationship (SAR). The present review is being obliging for the future development of pyrrole therapeutics. (C) 2015 Elsevier Masson SAS. All rights reserved.
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