期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 42, 期 18, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.202100019
关键词
alveoli; amphiphilic materials; gas‐ responsive materials; RAFT; self‐ assembly; triblock copolymers
资金
- National Natural Science Foundation of China [21704001]
- China Petrochemical Corporation [H2019485]
- Beijing Advanced Innovation Center for Soft Matter Science and Engineering
A amphiphilic triblock copolymer with gas-responsive segments was designed and synthesized to mimic the formation, respiration, and apoptosis of alveoli. The morphological transitions driven by gas stimulation successfully imitated the functions of alveoli, providing an essential basis for revealing life phenomena.
In human body, alveoli are the primary sites for gas exchange which are formed by the dilation and protrusion of bronchioles at the end of the lung, and the rapid gas-exchanging process in the alveoli ensures normal life activities. Based on the unique structures and functions of alveoli, it is necessary to study the regulation mechanism of its formation, respiration, and apoptosis. Herein, a class of reversible addition-fragmentation chain transfer (RAFT)-derived amphiphilic triblock copolymers, PEO-b-P(DEAEMA-co-FMA)-b-PS is designed and synthesized. Due to the amphiphilic and gas-responsive segments, these triblock copolymers can self-assemble in aqueous solution and undergo the morphological transition from nanotubes to vesicles under gas stimulation; meanwhile, in the cycles of CO2/O-2 stimulation, these vesicles can further realize the volume expansion and contraction, eventually rupture. The gas-driven morphological transformations of these aggregates successfully imitate the formation, respiration, and apoptosis of alveoli, and provide an essential basis for revealing the life phenomena.
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