期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 112, 期 -, 页码 60-65出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2016.02.013
关键词
Miconazole analogs; 1,2,3-Triazole derivatives; Antifungal activity; Azide-enolate cycloaddition
资金
- Secretaria de Investigation y Estudios Avanzados/UAEMex [3804/2014/CID]
- CONACYT-Mexico [227581, 273644]
Seven miconazole analogs involving 1,4,5-tri and 1,5-disubstituted triazole moieties were synthesized by azide-enolate 1,3-dipolar cycloaddition. The antifungal activity of these compounds was evaluated in vitro against four filamentous fungi, including Aspergillus fumigatus, Trichosporon cutaneum, Rhizopus oryzae, and Mucor hiemalis as well as three species of Candida spp. as yeast specimens. These pre-clinical studies suggest that compounds 4b, 4d and 7b can be considered as drug candidates for future complementary biological studies due to their good/excellent antifungal activities. (C) 2016 Elsevier Masson SAS. All rights reserved.
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