Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Injectable dual crosslinking hydrogels hold great promise to improve therapeutic efficacy in minimally invasive surgery. Compared with prefabricated hydrogels, injectable hydrogels can be implanted more accurately into deeply enclosed sites and repair irregularly shaped lesions, showing great applicable potential. Here, the current fabrication considerations of injectable dual crosslinking hydrogels are reviewed. Besides, the progress of the hydrogels used in corresponding applications and emerging challenges are discussed, with detailed emphasis in the fields of bone and cartilage regeneration, wound dressings, sensors and other less mentioned applications for their more hopeful employments in clinic. It is envisioned that the further development of the injectable dual crosslinking hydrogels will catalyze their innovation and transformation in the biomedical field.

Automated summary

Injectable dual crosslinking hydrogels show great promise in improving therapeutic efficacy in minimally invasive surgery, with accurate implantation into deeply enclosed sites and repair of irregular lesions. Current fabrication considerations and application progress are important for their further development and transformation in the biomedical field.