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Mitochondria-associated membrane-modulated Ca2+ transfer: A potential treatment target in cardiac ischemia reperfusion injury and heart failure

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Summary: Energy deprivation triggers mitochondrial fission and autophagy, while also increasing the number of mitochondrial-associated ER membranes (MAMs) through AMP-activated protein kinase (AMPK) activity. AMPK translocates to MAMs and interacts with mitofusin 2 (MFN2) during energy stress, regulating autophagy and MAM dynamics. MFN2 plays a critical role in cell survival and function under energy stress, highlighting the importance of the AMPK-MFN2 pathway in cellular stress response.

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