期刊
LIFE SCIENCES
卷 273, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2021.119150
关键词
CD47; Immune checkpoint blockers; Cancer immunotherapy; Combination therapies
资金
- Department of Finance of Jilin Province of China [201817260815, 2019SCZT048]
- Department of Science and Technology of Jilin Province [20190201238JC, 20190103113JH]
- National Key Research and Development Program of China [2017YFA0505300]
- National Natural Science Foundation of China [21727816, 21721003, 21703231]
- Laboratory for Marine Biology and Biotechnology, Pilot Qingdao National Laboratory for Marine Science and Technology [MS2018NO08]
CD47, as a transmembrane protein, plays a crucial role in modulating immune evasion of tumor cells. In recent years, CD47-SIRP alpha immune checkpoint inhibitors have gained increasing attention for their potential in tumor immunotherapy. Understanding the function of CD47 in the tumor microenvironment has accelerated the development of treatment strategies targeting this immune checkpoint.
As a transmembrane protein, CD47 plays an important role in mediating cell proliferation, migration, phagocytosis, apoptosis, immune homeostasis, inhibition of NO signal transduction and other related reactions. Upon the interaction of innate immune checkpoint CD47-SIRP alpha occurrence, they send a don't eat me signal to the macrophages. This signal ultimately helps tumors achieve immune escape by inhibiting macrophage contraction to prevent tumor cells from phagocytosis. Therefore, the importance of CD47-SIRP alpha immune checkpoint inhibitors in tumor immunotherapy has attracted more attention in recent years. Based on the cognitive improvement of the effect with CD47 in tumor microenvironment and tumor characteristics, the pace of tumor treatment strategies for CD47-SIRP alpha immune checkpoint inhibitors has gradually accelerated. In this review, we introduced the high expression of CD47 in cancer cells to avoid phagocytosis by immune cells and the importance of CD47 in the structure of cancer microenvironment and the maintenance of cancer cell characteristics. Given the role of the innate immune system in tumorigenesis and development, an improved understanding of the antitumor process of innate immune checkpoint inhibitors can lay the foundation for more effective combinations with other anti-tumor treatment strategies.
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