期刊
EUROPEAN JOURNAL OF MEDICAL GENETICS
卷 59, 期 3, 页码 116-125出版社
ELSEVIER
DOI: 10.1016/j.ejmg.2016.01.008
关键词
Cancer susceptibility; Childhood cancer; Selection tool; Congenital anomalies; Family history; Dysmorphisms
资金
- KiKa Foundation [KiKa-127, KiKa-150]
Genetic predisposition for childhood cancer is under diagnosed. Identifying these patients may lead to therapy adjustments in case of syndrome-related increased toxicity or resistant disease and syndrome-specific screening programs may lead to early detection of a further independent malignancy. Cancer surveillance might also be warranted for affected relatives and detection of a genetic mutation can allow for reproductive counseling. Here we present an easy-to-use selection tool, based on a systematic review of pediatric cancer predisposing syndromes, to identify patients who may benefit from genetic counseling. The selection tool involves five questions concerning family history, the type of malignancy, multiple primary malignancies, specific features and excessive toxicity, which results in the selection of those patients that may benefit from referral to a clinical geneticist. (C) 2016 The Authors. Published by Elsevier Masson SAS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据