期刊
LASERS IN MEDICAL SCIENCE
卷 37, 期 1, 页码 563-571出版社
SPRINGER LONDON LTD
DOI: 10.1007/s10103-021-03298-x
关键词
Photobiomodulation; Anti-inflammatory; Inflammation; Vascular actions; Laser; Edema
资金
- National Council for Scientific and Technological Development (CNPq)
Photobiomodulation therapy (PBMT) is a non-thermal therapeutic procedure used in clinical practice for treating various inflammatory conditions with fewer adverse effects compared to conventional therapy. This study investigated the effects of two different doses of PBMT on experimental models of inflammation, showing that 1 J/cm(2) of PBMT improved paw edema and reduced histological scores induced by phlogistic agents. PBMT at 1 J/cm(2) also demonstrated beneficial effects on carrageenan-induced edema and inhibited neutrophil migration.
Photobiomodulation therapy (PBMT) is a non-thermal therapeutic procedure widely used in clinical practice. It is considered an effective modality of treatment for the control of various inflammatory conditions with fewer adverse effects as compared to conventional therapy. However, despite the clinical effects, the mechanisms of action and dosimetric parameters of PBMT are not fully understood. This study was performed to describe the effects of two different doses of PBMT on experimental models of inflammation. Male Swiss mice were administered with 0.9% of saline or phlogistic agents (carrageenan, dextran, serotonin, histamine, or bradykinin) by intra-plantar injection and were treated with PBMT at a dose of 1 or 5 J/cm(2); right after, the variation of the paw volume was made, and histopathological analysis and myeloperoxidase assay of the carrageenan-induced edematous paw tissues were performed. The action of PBMT on carrageenan-induced vascular permeability was further evaluated. Our results showed that PBMT (1 J/cm(2)) led to an improvement in paw edema induced by the phlogistic agents and further reduced the histological scores. Inhibition of neutrophil migration was observed following the administration of 1 and 5 J/cm(2) of PBMT. However, only 1 J/cm(2) of PBMT showed beneficial effects on carrageenan-induced edema. Laser at a dose of 1 J/cm(2) showed cellular and vascular effects since it was able to reverse all the inflammatory parameters, and laser at a dose of 5 J/cm(2) probably has only cellular effects in the presence of acute inflammation.
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