Surface Wettability of a Natural Rubber Composite under Stretching: A Model to Predict Cell Survival

We report the stress-strain effect of a stretchable natural rubber (NR)-calcium phosphate composite on the surface wettability (SW) using an innovative approach coupling a uniaxial tensile micromachine, goniometer, and microscope. In situ contact angle measurements in real time were performed during mechanical tension. Our results show that SW is guided by the stress-strain relationship with two different characteristics, depending on the static or dynamic experiments. The results evidenced the limits of the classical theory of wetting. Furthermore, based on the mechanically tunable SW of the system associated with the cytocompatibility of the NR composite, we have modeled such a system for application as a cell support. From the experimental surface energy value, our proposed 3D modeling numerical simulation predicted a window of opportunities for cell-NR survival under mechanical stimuli. The presented data and the thermodynamics-based theoretical approach enable not only accurate correlation of SW with mechanical properties of the NR composite but also provide huge potential for future cell supportability in view of tissue engineering.

Automated summary

This study investigates the stress-strain effect of a stretchable natural rubber-calcium phosphate composite on surface wettability, revealing two different characteristics of SW in static and dynamic experiments. The research has implications for developing cell support materials in tissue engineering and offers potential applications for the mechanically tunable SW of the system. The results also challenge the traditional wetting theory and provide a theoretical basis for accurate correlation of SW with mechanical properties of the composite.