期刊
LANGMUIR
卷 37, 期 14, 页码 4137-4146出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.0c03640
关键词
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资金
- National Natural Science Foundation of China [31870564]
- Tianjin University of Science and Technology Young Teacher Innovation Foundation [2017LG09]
In this study, sea urchin-like rGO-TEPA/HA hollow microspheres were prepared via microwave hydrothermal synthesis, showing promising applications as bone drug carriers based on their noncytotoxicity in vitro experiments.
Hydroxyapatite ( HA) is the main inorganic component of human bones and teeth. It has good biocompatibility and bioactivity, which promotes its good application prospects in the field of bone drug carriers. In this study, tetraethylenepentamine-graphene (rGO-TEPA)/CaCO3:HA composite microspheres were prepared via microwave hydrothermal synthesis using rGO-TEPA/CaCO3 solid microspheres as intermediates. Furthermore, the incompletely transformed CaCO3 was removed by soaking in a citric acid buffer to obtain rGO-TEPA/HA hollow composite microspheres. The two types of as-prepared composite microspheres exhibited sea urchin-like structures, large BET surface areas, and good dispersibility. Mouse preosteoblast cells (MC3T3-E1) were used for in vitro cytotoxicity experiments. The in vitro cell viability test showed that the two composite drug carriers exhibited noncytotoxicity. Moreover, the doxorubicin (DOX) loading and releasing investigations revealed that the two types of prepared carriers had mild storage-release behaviors and good pH responsiveness. Hence, these rGO-TEPA/HA hollow microspheres have promising applications as bone drug carriers.
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