期刊
LANGENBECKS ARCHIVES OF SURGERY
卷 406, 期 8, 页码 2591-2609出版社
SPRINGER
DOI: 10.1007/s00423-021-02171-3
关键词
Gastroesophageal reflux disease (GERD); Sleeve gastrectomy; Manometry; pH-metry; 24h-pH-impedance
类别
资金
- Universita degli Studi di Roma La Sapienza within the CRUI-CARE Agreement
This systematic review aimed to evaluate the changes in esophageal motility and acid exposure before and after laparoscopic sleeve gastrectomy (LSG) through esophageal manometry and 24-hours pH-monitoring. The results revealed a decrease in lower esophageal sphincter resting pressure and worsening DeMeester score and acid exposure time post-surgery, with a high rate of de novo GERD. Further long-term studies are needed to understand the clinical impact of LSG and the burden of GERD over time.
Purpose Aim of this systematic review is to assess the changes in esophageal motility and acid exposure of the esophagus through esophageal manometry and 24-hours pH-monitoring before and after laparoscopic sleeve gastrectomy (LSG). Methods Articles in which all patients included underwent manometry and/or 24-hours pH-metry or both, before and after LSG, were included. The search was carried out in the PubMed, Embase, Cochrane, and Web of Science databases, revealing overall 13,769 articles. Of these, 9702 were eliminated because they have been found more than once between the searches. Of the remaining 4067 articles, further 4030 were excluded after screening the title and abstract because they did not meet the inclusion criteria. Thirty-seven articles were fully analyzed, and of these, 21 further articles were excluded, finally including 16 articles. Results Fourteen and twelve studies reported manometric and pH-metric data from 402 and 547 patients, respectively. At manometry, a decrease of the lower esophageal sphincter resting pressure after surgery was observed in six articles. At 24-hours pH-metry, a worsening of the DeMeester score and/or of the acid exposure time was observed in nine articles and the de novo gastroesophageal reflux disease (GERD) rate that ranged between 17.8 and 69%. A meta-analysis was not performed due to the heterogeneity of data. Conclusions After LSG a worsening of GERD evaluated by instrumental exams was observed such as high prevalence of de novo GERD. However, to understand the clinical impact of LSG and the burden of GERD over time further long-term studies are necessary.
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