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Article
Medicine, General & Internal
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
Merryn Voysey et al.
Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.
LANCET (2021)
Editorial Material
Medicine, General & Internal
SARS-CoV-2 variants and ending the COVID-19 pandemic
Arnaud Fontanet et al.
LANCET (2021)
Article
Multidisciplinary Sciences
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
Zijun Wang et al.
Summary: Volunteers who received the Moderna or Pfizer-BioNTech vaccine showed high levels of antibodies and memory B cell responses against SARS-CoV-2, with activity similar to individuals who had recovered from natural infection. However, their efficacy against specific SARS-CoV-2 variants was reduced, indicating a potential need for periodic updates to mRNA vaccines to maintain clinical efficacy.
NATURE (2021)
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