4.6 Article

Sequence-Function Relationships in Phage-Encoded Bacterial Cell Wall Lytic Enzymes and Their Implications for Phage-Derived Product Design

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Summary: This study explored the roles of different domains in the PlySK1249 endolysin and how they synergize for bacterial lysis. The Ami and CHAP domains work together to digest peptidoglycan efficiently, while proteolytic cleavage by host cell wall proteases may modulate the enzyme's lytic activity. Understanding the multidomain interplay of endolysins like PlySK1249 can contribute to the development of more effective therapeutic antibacterial agents.

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