期刊
JOURNAL OF THORACIC ONCOLOGY
卷 16, 期 5, 页码 873-877出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jtho.2021.02.005
关键词
Case report; ALK rearrangement; Lung cancer; Alectinib; Pregnancy
This case report presents a female patient with ALK-rearranged metastatic lung adenocarcinoma who became pregnant while receiving alectinib treatment. With the collaborative effort of a multidisciplinary team, the patient continued the study drug throughout pregnancy and delivered a healthy baby girl. Both maternal and fetal parameters remained normal during the pregnancy, and the baby showed no developmental anomalies during the first 20 months of life. After 32 months from diagnosis, the mother is doing well and in partial remission.
This is the first case report of a patient with ALK-rearranged metastatic lung adenocarcinoma who became pregnant during treatment with alectinib. A multidisciplinary team of gynecologists, neonatologists, oncologists, psychologists, and pharmacologists was set up to handle the case. According to patient's preference, the study drug was continued throughout pregnancy and the woman delivered a healthy baby girl at 35 weeks and 5 days of gestation. Fetal parameters remained normal during pregnancy. At birth, alectinib levels were 14 times higher in maternal plasma than in the fetus (259 versus 18 ng/mL). The average concentration of alectinib in the placenta was 562 ng/g. The baby was followed during her first 20 months, and no developmental anomalies were observed. After 32 months from diagnosis, the mother is well and in partial remission.
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