期刊
EUROPEAN JOURNAL OF INTERNAL MEDICINE
卷 29, 期 -, 页码 3-8出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejim.2015.11.026
关键词
Uric acid; Metabolic syndrome; Hypertension; Diabetes mellitus; Kidney disease; Cardiovascular disease
资金
- NIDDK NIH HHS [R03 DK105041, K01 DK095930] Funding Source: Medline
Uric acid, once viewed as an inert metabolic end-product of purinemetabolism, has been recently incriminated in a number of chronic disease states, including hypertension, metabolic syndrome, diabetes, non- alcoholic fatty liver disease, and chronic kidney disease. Several experimental and clinical studies support a role for uric acid as a contributory causal factor in these conditions. Here we discuss some of the major mechanisms linking uric acid to metabolic and cardiovascular diseases. At this time the key to understanding the importance of uric acid in these diseases will be the conduct of large clinical trials in which the effect of lowering uric acid on hard clinical outcomes is assessed. Elevated uric acid may turn out to be one of the more important remediable risk factors for metabolic and cardiovascular diseases. (C) 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
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