期刊
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 32, 期 6, 页码 1293-1304出版社
AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2020040423
关键词
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资金
- Division of Nephrology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta Kidney Health Translational Research Chair grant/award
- Canadian Institutes of Health Research grant [MOP-102694]
The kidneys maintain stable blood perfusion by autoregulating blood flow through myogenic response and tubuloglomerular feedback (TGF) mechanisms, with nephrons communicating electrically over long distances to form the nephrovascular unit (NVU). This distributed autoregulation across the renal microvascular network optimizes oxygenation-perfusion matching and prevents transmission of high systemic pressure to the glomeruli, thus preventing progressive glomerular and vascular injury.
To perform their functions, the kidneys maintain stable blood perfusion in the face of fluctuations in systemic BP. This is done through autoregulation of blood flow by the generic myogenic response and the kidney-specific tubuloglomerular feedback (TGF) mechanism. The central theme of this paper is that, to achieve autoregulation, nephrons do not work as single units to manage their individual blood flows, but rather communicate electrically over long distances to other nephrons via the vascular tree. Accordingly, we define the nephrovascular unit (NVU) to be a structure consisting of the nephron, glomerulus, afferent arteriole, and efferent arteriole. We discuss features that require and enable distributed autoregulation mediated by TGF across the kidney. These features include the highly variable topology of the renal vasculature which creates variability in circulation and the potential for mismatch between tubular oxygen demand and delivery; the self-sustained oscillations in each NVU arising from the autoregulatory mechanisms; and the presence of extensive gap junctions formed by connexins and their properties that enable long-distance transmission of TGF signals. The existence of TGF synchronization across the renal microvascular network enables an understanding of how NVUs optimize oxygenation-perfusion matching while preventing transmission of high systemic pressure to the glomeruli, which could lead to progressive glomerular and vascular injury.
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