期刊
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
卷 -, 期 3, 页码 574-580出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201601185
关键词
Metal-organic frameworks; Zinc; Antibiotics; N,O ligands
资金
- FP7-ERANet Susfood [2014/00153/001]
- Spanish Ministry of Economy and Competitiveness [CTM2013-45775-C2-1-R, CTQ2014-58270-R]
- Direccion General de Universidades e Investigacion de la Comunidad de Madrid, Research Network [S2013/MAE-2716]
- Factoria de Cristalizacion-Consolider-Ingenio [CSD2006-00015]
- Alcala University, Spain [CCG10UAH/PPQ-5925]
A Zn-based metal-organic framework (MOF) with hydrazinebenzoate linkers was evaluated as antimicrobial material against the Gram-positive bacterium Staphylococcus aureus. The material inhibits bacterial growth and metabolic activity, with a half maximal effective concentration of about 20 mg L-1 material dispersed in the culture medium. The antimicrobial effect can be attributed to the release of the 4-hydrazinebenzoate linker, with a negligible contribution from the free metal. The material exhibits remarkable durability, and it enables the sustained release of the ligand over a period of several days.
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