SALE-Ing a MOF-Based Ship of Theseus. Sequential Building-Block Replacement for Complete Reformulation of a Pillared-Paddlewheel Metal-Organic Framework

A complete structure and composition evolution of a pillared-paddlewheel metal-organic framework was achieved using a combination of solvent-assisted linker exchange (SALE) and node transmetalation. In this example, each building unit - the di-topic carboxylate strut, the di-topic nitrogen-based pillar, and the di-zinc node - of the original metal-organic framework is replaced in sequential fashion to produce a nickel-based daughter metal-organic framework with entirely different components.