Reducing Challenges in Organic Synthesis with Stereoselective Hydrogenation and Tandem Catalysis

Tandem catalysis enables the rapid construction of complex architectures from simple building blocks. This Perspective shares our interest in combining stereoselective hydrogenation with transformations such as isomerization, oxidation, and epimerization to solve diverse challenges. We highlight the use of tandem hydrogenation for preparing complex natural products from simple prochiral building blocks and present tandem catalysis involving transfer hydrogenation and dynamic kinetic resolution. Finally, we underline recent breakthroughs and opportunities for asymmetric hydrogenation.

Automated summary

Tandem catalysis allows for constructing complex structures quickly from simple building blocks to address diverse challenges. This article focuses on using tandem hydrogenation to prepare complex natural products and presents tandem catalysis involving transfer hydrogenation. Lastly, recent breakthroughs and opportunities for asymmetric hydrogenation are highlighted.